I previously mentioned that three of the pre-set radio stations in my truck are to NPR -- variously Jacksonville, Gainesville, and Orlando. As I drive across Florida to seminary and back, I generally rotate as a signal dies and a new one emerges. I don't always agree with what's said on NPR, but I rarely feel stupider after having listened to it.
I used to really like This American Life, but haven't listened to it in years due to scheduling conflicts. So if I had to choose, I'd say Terry Gross' Fresh Air.